01 - Preheat oven to 375°F and lightly grease a 9x13 inch baking dish with cooking spray or a small amount of oil.
02 - Pat chicken breasts dry with paper towels and season both sides generously with salt and black pepper. Arrange seasoned chicken in the prepared baking dish in a single layer.
03 - In a medium bowl, combine mayonnaise (or Greek yogurt), 1/2 cup Parmesan cheese, garlic powder, onion powder, paprika, and dried parsley. Mix thoroughly until all ingredients are fully incorporated into a smooth, creamy mixture.
04 - Spread the sauce mixture evenly over the tops of each chicken breast, ensuring complete coverage. The sauce should be thick enough to adhere without running off.
05 - Sprinkle the remaining 1/4 cup Parmesan cheese evenly over the sauced chicken. If desired, add breadcrumbs for additional texture and crunch.
06 - Place baking dish in the preheated oven and bake uncovered for 25 to 30 minutes. The chicken is done when it reaches an internal temperature of 165°F and the topping is golden brown and bubbly.
07 - Remove from oven and allow chicken to rest for 5 minutes before serving. This resting period allows juices to redistribute throughout the meat. Garnish with additional fresh parsley if desired.